Surescripts, founded in 2001, operates the largest health intelligence network in the United States, enabling the exchange of health information across the healthcare ecosystem. The network connects over 2.32 million healthcare professionals and provider organizations, processing more than 30.5 billion transactions in 2025. Its infrastructure supports a range of participants including pharmacies, health plans, pharmacy benefit managers, health systems, EHR vendors, and life sciences companies.
The company's core technical domains centre on health information exchange, e-prescribing, and network infrastructure. Its product suite includes Electronic Prior Authorization, Real-time Prescription Benefit Tools, Medication History Services, e-prescribing for both routine and controlled substances, Formulary Management, and Clinical Direct Messaging between healthcare providers.
For those working in applied AI, the scale and nature of Surescripts' network present significant technical challenges. The volume of structured health data flowing through its systems, combined with the need for real-time processing and interoperability across diverse healthcare stakeholders, offers opportunities in areas such as clinical decision support, data quality, and network optimisation.
